All About Amlodipine Oral Tablet


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What is amlodipine oral tablet?

If you have certain heart conditions, your doctor may prescribe amlodipine oral tablet for you.

It’s a prescription drug that’s used to treat high blood pressure in adults and some children. It’s also used to treat coronary artery disease (CAD) in adults. (CAD prevents your arteries from supplying enough blood to your heart. And this can lead to angina, which is a type of chest pain.)

For high blood pressure and CAD, you may take amlodipine oral tablets with other drugs.

To learn more about these conditions and how amlodipine is used to treat them, see the “What is amlodipine oral tablet used for?” section below.

Amlodipine oral tablet basics

Amlodipine oral tablet contains the active drug amlodipine besylate. This drug is classified as a calcium channel blocker.

You’ll take amlodipine oral tablets by mouth.

Note: Amlodipine also comes as an oral suspension (a type of liquid mixture). But only the oral tablet is described in this article. If you’d like to learn about amlodipine’s other form, talk with your doctor or pharmacist.

Amlodipine oral tablet brand-name versions

Amlodipine oral tablet is a generic medication. But it is also available in a brand-name version called Norvasc.

Note: The oral suspension form of amlodipine has another brand-name drug version. To learn about this other version, talk with your doctor or pharmacist.

Amlodipine oral tablet is a generic drug, which means it’s an exact copy of the active drug in a brand-name medication. The brand-name medication that amlodipine oral tablet is based on is called Norvasc.

Generic drugs are thought to be as safe and effective as the brand-name drug they’re based on. In general, generics usually cost less than brand-name drugs.

If you’d like to know more about using Norvasc instead of amlodipine oral tablet, talk with your doctor. And see this Healthline article to learn more about the differences between generic and brand-name drugs.

What are amlodipine oral tablet’s side effects?

Like most drugs, amlodipine oral tablet may cause mild or serious side effects. The lists below describe some of the more common side effects. These lists don’t include all possible side effects.

Keep in mind that side effects of a drug can depend on:

  • your age
  • the dosage you’re prescribed
  • other health conditions you have
  • other medications you may be taking

Your doctor or pharmacist can tell you more about the potential side effects of amlodipine oral tablet. They can also suggest ways to help reduce side effects.

Mild side effects

Here’s a short list of some of the mild side effects that amlodipine oral tablet can cause. To learn about other mild side effects, talk with your doctor or pharmacist, or read amlodipine oral tablet’s prescribing information.

Mild side effects of amlodipine oral tablet that have been reported include:

  • anxiety
  • belly pain
  • dizziness
  • erectile dysfunction (ED)
  • extreme drowsiness or sleepiness
  • fatigue (lack of energy)
  • flushing (temporary warmth, redness, or deepening of skin color)
  • heart palpitations (irregular or fast heartbeat)
  • joint pain
  • lowered heart rate
  • muscle problems, such as stiffness or tremor
  • nausea
  • peripheral neuropathy (nerve damage that causes symptoms such as leg pain)
  • weight gain*
  • edema (swelling)*
  • constipation*

Mild side effects of many drugs may go away within a few days or a couple of weeks. But if they become bothersome, talk with your doctor or pharmacist.

* For more information on this side effect, see the “Side effect focus” section below.

Serious side effects

Serious side effects from amlodipine oral tablet can occur, but they aren’t common. If you have serious side effects, call your doctor right away. However, if you think you’re having a medical emergency, you should call 911 or your local emergency number.

Serious side effects of amlodipine oral tablet that have been reported include:

  • angina (a type of chest pain) that’s worse than usual
  • heart attack
  • low blood pressure
  • allergic reaction*

* For more information on this side effect, see the “Side effect focus” section below.

Side effect focus

Learn more about some of the side effects amlodipine oral tablet may cause.

Weight gain

You may have weight gain while you’re taking amlodipine oral tablets. But this wasn’t a common side effect in studies of the drug.

You may also gain weight if you have edema (swelling), which is a possible side effect of amlodipine oral tablet. For more information about this, see the “Edema, such as leg swelling” section just below.

What might help

If you’re concerned about weight gain while taking amlodipine, talk with your doctor. They can recommend healthy ways to manage your weight.

Edema, such as leg swelling

You may have edema (swelling) while you’re taking amlodipine oral tablets. This was the most common side effect reported in studies of the drug.

Swelling from amlodipine oral tablets typically happens in your arms, feet, hands, or legs. Your risk for swelling with amlodipine may increase with higher doses of the drug.

What might help

Tell your doctor about any swelling you have while you’re taking amlodipine oral tablets. They may lower the dosage you’re prescribed. Or they may switch you to a different drug to treat your condition.

If your swelling is mild and isn’t bothersome, your doctor may tell you it’s safe to keep taking amlodipine oral tablets. To help lessen swelling while taking this drug, you can try the following remedies:

  • wear compression stockings or wraps on the swollen area
  • keep the swollen area elevated

If your swelling is severe or bothersome, your doctor may have you stop taking amlodipine oral tablets. If so, your swelling will likely go down within several days after stopping the drug.

Constipation

You may have constipation while you’re taking amlodipine oral tablets. But this wasn’t a common side effect in studies of the drug.

Constipation can cause symptoms such as:

  • having fewer bowel movements than usual
  • passing hard stools
  • taking a longer time than usual to pass stools

What might help

Tell your doctor if you have constipation while taking amlodipine oral tablets.

If you have constipation, it’s important to keep your body hydrated by drinking plenty of water. You can also try eating certain foods to help stay hydrated.

Eating foods rich in fiber can help relieve your constipation. These foods include whole grains, vegetables, and raw fruits.

Over-the-counter medications, such as laxatives and stool softeners, are also effective for relieving constipation. But make sure you check with your doctor or pharmacist before taking any new medications with amlodipine oral tablet.

Allergic reaction

Some people may have an allergic reaction to amlodipine oral tablet.

Symptoms of a mild allergic reaction can include:

  • skin rash
  • itchiness
  • flushing (temporary warmth, redness, or deepening of skin color)

A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include swelling under your skin, typically in your eyelids, lips, hands, or feet. They can also include swelling of your tongue, mouth, or throat, which can cause trouble breathing.

Call your doctor right away if you have an allergic reaction to amlodipine oral tablet. But if you think you’re having a medical emergency, call 911 or your local emergency number.

How is Amlodipine oral tablet taken?

Your doctor will explain how you should take amlodipine oral tablets. They will also explain how much to take and how often. Be sure to follow your doctor’s instructions. Below are commonly used dosages, but always take the dosage your doctor prescribes.

Taking amlodipine oral tablet

You’ll take amlodipine oral tablets by mouth.

Amlodipine oral tablets are available in three strengths:

  • 2.5 milligrams (mg)
  • 5 mg
  • 10 mg

Dosage

The usual dose range from amlodipine varies, depending on the reason your doctor prescribes the drug for you. Your dose will also be based on:

  • your age, as the recommended dosage may be lower for older people
  • other health conditions you may have

You’ll take amlodipine oral tablets once a day. The drug isn’t typically taken twice a day.

You can take your dose any time of day. But the drug can cause side effects such as extreme drowsiness, sleepiness, and fatigue (lack of energy). So you may want to take your dose at bedtime.

The maximum dose of amlodipine oral tablets is 10 mg per day.

Taking amlodipine oral tablet with other drugs

Amlodipine oral tablet may be used with other drugs that treat high blood pressure, coronary artery disease (CAD), and angina (a type of chest pain).

For high blood pressure, amlodipine may be used together with:

  • angiotensin-converting enzyme inhibitors, such as:

    • lisinopril (Zestril)
    • benazepril (Lotensin)
  • angiotensin II receptor blockers, such as:

    • valsartan (Diovan)
    • losartan (Cozaar)
  • thiazide diuretics, such as hydrochlorothiazide (Microzide)

For CAD and angina, amlodipine oral tablet may be used together with:

  • beta-blockers, such as:

    • metoprolol (Lopressor)
    • bisoprolol
  • nitrates, such as:
    • nitroglycerin (GoNitro)
    • isosorbide mononitrate (Imdur)

If you have questions about other drugs that are right for treating your condition, talk with your doctor.

Questions about taking amlodipine oral tablet

Here’s a list of common questions about taking amlodipine.

  • What if I miss a dose of amlodipine oral tablet? You can take your missed dose of amlodipine as soon as you remember. But if more than 12 hours have passed since you missed the dose, skip it and take your next dose at the normal time. Talk with your doctor or pharmacist if you aren’t sure whether to skip or take a missed dose of amlodipine oral tablet.
  • Will I need to use amlodipine oral tablet long term? Yes, most likely. You’ll probably take amlodipine long term if it’s working for you and isn’t causing bothersome side effects. Your doctor will tell you the right length of time to take amlodipine oral tablets.
  • Can amlodipine oral tablet be chewed, crushed, or split? The manufacturer of amlodipine oral tablet hasn’t stated whether the drug can be chewed, crushed, or split. If you have trouble swallowing amlodipine tablets whole, talk with your doctor or pharmacist.
  • Should I take amlodipine oral tablet with food? You can take amlodipine oral tablets with food or without it.
  • How long does amlodipine oral tablet take to work? Amlodipine oral tablets start working right away to treat your condition. But it may take a couple of days after your first dose for the drug to start lowering your blood pressure or easing your chest pain.

Questions for your doctor

You may have questions about amlodipine oral tablet and your treatment plan. It’s important to discuss all your concerns with your doctor.

Here are a few tips that might help guide your discussion:

  • Before your appointment, write down questions like:
    • How will amlodipine oral tablet affect my body, mood, or lifestyle?
  • Bring someone with you to your appointment if doing so will help you feel more comfortable.
  • If you don’t understand something related to your condition or treatment, ask your doctor to explain it to you.

Remember, your doctor and other healthcare professionals are available to help you. And they want you to get the best care possible. So don’t be afraid to ask questions or offer feedback on your treatment.

What are some frequently asked questions about Amlodipine oral tablet?

Find answers to some commonly asked questions about amlodipine oral tablet.

What are some alternative drugs to amlodipine?

Amlodipine is prescribed to treat high blood pressure, coronary artery disease, and angina (a type of chest pain). It belongs to a group of drugs called calcium channel blockers.

Other medications are also used to treat these conditions. Below are a few alternatives to amlodipine:

  • angiotensin-converting enzyme inhibitors, such as:

    • lisinopril (Zestril)
    • benazepril (Lotensin)
  • angiotensin II receptor blockers, such as:

    • valsartan (Diovan)
    • losartan (Cozaar)
  • beta-blockers, such as:

    • metoprolol (Lopressor)
    • bisoprolol
  • statins, such as simvastatin (Zocor)
  • calcium channel blockers, other than amlodipine, such as nifedipine (Procardia)

Each drug listed above works differently in your body to lower blood pressure or help supply blood to your heart. If you have questions about how amlodipine and its alternatives are alike and different, talk with your doctor.

Is amlodipine a beta-blocker, ACE inhibitor, or diuretic?

No, amlodipine isn’t a beta-blocker, angiotensin-converting enzyme (ACE) inhibitor, or diuretic.

Amlodipine belongs to a group of drugs called calcium channel blockers. Calcium channel blockers, beta-blockers, ACE inhibitors, and diuretics are used to treat similar conditions. But the drugs work in different ways in your body.

If you have questions about how amlodipine is different from these other types of drugs, talk with your doctor or pharmacist.

Will I have side effects when stopping amlodipine?

Yes, you may have certain side effects when stopping amlodipine. Your symptoms can depend on the reason you’re taking the drug.

For example:

  • If you take amlodipine for high blood pressure, it’s likely your blood pressure will increase after you stop taking the drug.
  • If you take amlodipine to treat coronary artery disease and angina (a type of chest pain), you may start having chest pain again after the drug is stopped.

Do not stop taking amlodipine unless your doctor says it’s safe to do so. If they recommend that you should stop amlodipine, it’s likely your doctor will decrease your dose slowly over time. This can help lessen any side effects that you may have from stopping the drug.

What’s amlodipine’s half-life? How long does it stay in your system?

The half-life of a drug is the time it takes for half of a dose of the drug to leave your body. Amlodipine’s half-life is 30 to 50 hours. In other words, it takes about 30 to 50 hours for your body to get rid of half of a dose of amlodipine.

It usually takes about five half-lives for a drug to leave your system entirely. For amlodipine, this means the drug will stay in your system for about 10 days after your last dose.

Does amlodipine cause hair loss?

No, it isn’t likely that you’ll have hair loss with amlodipine. Hair loss wasn’t seen in studies of the drug.

If you have hair loss while you’re taking amlodipine, talk with your doctor. They can check to see if something else is causing this condition.

Will I have a cough when using amlodipine?

No, you probably won’t have a cough when taking amlodipine. A cough wasn’t a side effect reported in studies of the drug.

But you may take other drugs together with amlodipine that can cause a cough. For example, angiotensin-converting enzyme (ACE) inhibitors may cause a cough. Examples of ACE inhibitors include lisinopril (Zestril) and benazepril (Lotensin).

So if you have a cough while you’re taking amlodipine with these drugs, it’s likely caused by the ACE inhibitor and not by amlodipine.

If you have a bothersome cough while you’re taking amlodipine, talk with your doctor. They can recommend ways to treat your cough.

What should be considered before taking amlodipine oral tablet?

When considering amlodipine oral tablet, it’s important to talk with your doctor. Discuss your overall health with them and tell them about any other health conditions you have.

Below are a few things you should consider before taking amlodipine.

Interactions

Taking medications, vaccines, foods, and other things with a certain drug can affect how the drug works. These effects are called interactions.

Before taking amlodipine oral tablets, be sure to tell your doctor about all medications you take, including prescription and over-the-counter types. Also describe any vitamins, herbs, or supplements you use. Your doctor or pharmacist can tell you about any interactions these items may cause with amlodipine oral tablet.

Interactions with drugs or supplements

Amlodipine oral tablet can interact with several types of drugs. These drugs include:

  • drugs that block an enzyme (type of protein) in your body called CYP3A
  • the immunosuppressant drugs cyclosporine (Gengraf) and tacrolimus (Prograf)
  • the erectile dysfunction (ED) or pulmonary arterial hypertension (PAH) drug sildenafil (Viagra, Revatio)
  • the high cholesterol drug simvastatin (Zocor), when it’s used at doses higher than 20 mg

This list does not contain all types of drugs that may interact with amlodipine oral tablet. Your doctor or pharmacist can tell you more about these interactions and any others that may occur with use of amlodipine oral tablet.

Warnings

Amlodipine oral tablet may not be right for you if you have certain medical conditions or other factors that affect your health. Conditions that prevent you from taking a drug are sometimes called “contraindications.”

Talk with your doctor about your health history before you take amlodipine oral tablets. Factors to consider include those in the list below.

  • Heart problems. Before taking amlodipine oral tablets, tell your doctor if you have heart conditions that cause very narrow heart valves or arteries. These conditions include aortic stenosis and obstructive coronary artery disease. These heart problems can raise your risk for low blood pressure, heart attack, or worsened angina (a type of chest pain) after taking amlodipine.
  • Liver problems. If you have liver problems, such as liver failure, tell your doctor before starting amlodipine oral tablets. Your body won’t break down amlodipine as effectively if you have liver problems. So your doctor will likely give you lower doses of amlodipine.
  • Allergic reaction. If you’ve had an allergic reaction to amlodipine oral tablet or any of its ingredients, you should not take this drug. Ask your doctor about other medications that might be better options for you.

Use with alcohol

There aren’t any known issues with drinking alcohol while taking amlodipine oral tablets.

If you drink alcohol, talk with your doctor about the amount that’s safe for you to drink while taking this drug.

Pregnancy and breastfeeding

It’s not known if amlodipine oral tablets are safe to use while pregnant or breastfeeding.

If you’re pregnant or planning a pregnancy while taking amlodipine, talk with your doctor. They can discuss the risks and benefits of taking amlodipine oral tablets during pregnancy.

It’s recommended that you do not breastfeed while taking amlodipine. The nursing implications for the drug are not known. If you’re breastfeeding or planning to breastfeed, your doctor may prescribe a drug other than amlodipine for you.

What is amlodipine oral tablet used for?

If you have certain heart conditions, your doctor may prescribe amlodipine oral tablet for you.

This drug is prescribed to treat high blood pressure. It’s used for this purpose in adults and children ages 6 years and older.

High blood pressure typically develops over the course of several years. Usually, you don’t notice any symptoms from it. But it can make your heart work harder than normal to pump blood through your body.

But even without symptoms, high blood pressure can cause damage to your blood vessels and organs. It can especially affect your brain, heart, eyes, and kidneys.

Amlodipine oral tablet is also prescribed to treat coronary artery disease (CAD) in adults. CAD is a condition that causes your blood vessels to narrow, which lessens blood flow to your heart. This leads to angina (a type of chest pain).

Amlodipine oral tablet is used to treat these specific types of CAD:

  • chronic (long-lasting) stable angina (a type of chest pain that happens in a predictable pattern)
  • vasospastic angina (a type of chest pain that happens suddenly)
  • CAD without heart failure

CAD causes impaired blood flow in the arteries that supply blood to your heart. This condition can increase your risk for heart attack if it’s not diagnosed and treated.

For both high blood pressure and CAD, you may take amlodipine oral tablets together with other drugs.

Amlodipine oral tablet is a type of drug called a calcium channel blocker. It works by widening your blood vessels. This helps lower your blood pressure and improves blood flow to your heart, which reduces chest pain.

What does amlodipine oral tablet cost?

Costs of prescription drugs can vary depending on many factors. These factors include what your insurance plan covers and which pharmacy you use. To find current prices for amlodipine oral tablet in your area, visit GoodRx.com.

Financial assistance to help you pay for amlodipine oral tablet may be available. Medicine Assistance Tool and NeedyMeds are two websites that provide resources to help reduce the cost of Amlodipine oral tablet.

They also offer tools to help you find low-cost healthcare and certain educational resources. To learn more, visit their websites.

What should be done in case of overdose?

Do not take more amlodipine oral tablets than your doctor prescribes. Using more than this can lead to serious side effects.

Symptoms of overdose

Symptoms caused by an overdose can include low blood pressure that leads to an increased heart rate.

What to do in case you take too much amlodipine oral tablet

Call your doctor if you think you’ve taken too much amlodipine oral tablet. You can also call 800-222-1222 to reach the American Association of Poison Control Centers, or use their online resource. However, if you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room.

What to ask your doctor

If you have questions about using amlodipine for high blood pressure, coronary artery disease (CAD), or angina (a type of chest pain), talk with your doctor.

You may want to ask about other treatment options for these conditions. Below are a few articles you may find helpful:

  • A List of Blood Pressure Medications
  • High Blood Pressure Treatment
  • Drugs for CAD: A Guide to Medications for Coronary Artery Disease
  • What to Know About Treating Coronary Artery Disease

Additionally, here’s a list of questions you may want to ask your doctor about amlodipine oral tablet:

  • Does amlodipine interact with any foods or drugs I take, such as grapefruit or ibuprofen?
  • How is amlodipine different from other drugs that treat high blood pressure or CAD?
  • Should I use other treatments for high blood pressure or CAD while taking amlodipine?

To stay informed about heart health, sign up here for the Healthline heart health newsletter.

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.


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